Folate; friendly or enemy nutrient

Folate is one of the water-soluble vitamins. This vitamin functions in cell cycle and gene replication and has dragged researcher’s attention to itself. The policy of food enrichment with Acid Folic can be beneficial for decrease of nerve tube defect while its enrichment can affect cancer risk,especially breast cancer in women population which is the target group of Acid folic supplement intake or enriched food with Acid Folic, and this issue has caused Folate Controversy. The aim of this review study is investigation of Folate’s role in incidence of breast cancer.Method: This review study is based on searching key words of Folic Acid, folate and Breast Cancer in PubMed and ISI data bases and selecting cohort studies since 2005 to 2014. Based on this information 8 articles were surveyed.Results: Investigating of these studies indicates that high amount of Folate intake from supplements or enriched foods is significantly related to increase the risk of cancer .There was no difference in taking folate from supplements or enriched foods.Conclusions: Although Acid Folic supplements and Acid Folic enriched foods caused significant decrease in NTD incidence, regarding its role in cell replication, it can be influential in cancer risk.According to available evidence concerning folate intake with developing cancer, is a U-shapedcurve.. Based on these studies, Folate intake less than 150 mcg can be effective in genetic mutations and its intake more than 1mg is involved in increased cell replication