The effect of conjugated linoleic acids on breast cancer: a systematic review

Background: Recently prevention strategies for breast cancer are focused on lifestyle modification such as diet. Some dietary factors such as Conjugated linoleic acid can lower the breast cancer risk. Many studies have been done in this field but their results are inconsistent. Therefore, we evaluated this association based on systematic review among published scientific literature. Methods: We performed an electronic search using PubMed, Cochrane, Scopus Google Scholar, Persian database (Iran Medex, magiran) to identify relevant studies. We summarized the findings of 8 papers in this review. Results: Although, three cohort studies were not overall identified a protective effect of Conjugated linoleic acid on breast cancer, one of them showed an inverse association after adjusting for age. Also, this impact was seen when the Conjugated linoleic acid intake of population were examined as usual daily food consumption. Also, among case-control studies, a weak inverse association among post-menopausal women was reported. Besides, a clinical trial showed that some indicator of breast tumor decreased after CLA administration among women with breast adenocarcinoma. Conclusions: Lacking published evidence suggested inconsistent results. So, further well designed studies are .

Keywords:

Systematic review , breast cancer , conjugated linoleic acid