ration of spherical super magnetic iron oxide nanoparticles and its application as drug delivery systems

In this research, spherical superparamagnetic iron oxide nanoparticles with mean diameter of 6 -10 nmwere prepared by a reduction–precipitation method. The surface of spherical superparamagnetic iron oxidenanoparticles SPION were coated with poly (methacrylic acid) (PMAA) and followed by loading with the anticancerdrug DOX (doxorubicin). The drug loading efficiency was (14.64 ± 0.29). In vitro drug release studies were realizedfor 8 h at two different pH values. The drug release rate at acidic pH was much faster than that at natural pH. Theseresults also indicate that DOX/PMAA nanoparticles have a favourable release property and drug release kineticsfollowed the Korsmeyer–Peppas model. The samples were characterized by XRD, SEM, TEM, FTIR, and UV-Vis.

Keywords:

Release kinetic studies , magnetite drug targeting , functionalization , poly(methacrylic acid) , anticancerdrug