Improvement of Celecoxib solubility using microemulsion systems

The aim of this study is to increase the solubility of an analgesic, antipyretic and antiinflammatorydrug named Celecoxib using two types of O/W and IL (ionic liquid)/W microemulsionsystems. The pseudo-ternary phase diagram was constructed and four microemulsion formulations wereselected (denoted as A, B, C, D) for drug loading. The physicochemical properties such as density, refractiveindex and electrical conductivity of the four different microemulsion formulations were measured. Thesolubility of the Celecoxib in the constructed formulations of two different types of O/W and IL/Wmicroemulsions were determined and compared. The results showed considerable increase in solubility ofthe drug in the microemulsion systems specially when containing ionic liquid.

Keywords:

Microemulsion systems , Ionic liquid , Drug delivery system