Inclusion Complex of β-CD-DZ as a nanocarrier: Preparation, Spectroscopic characterization, Thermodynamic parameters and molecular modelling Study
Publish place: 20th Iranian Conference on the Chemistry of Physics
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISPTC20_270
تاریخ نمایه سازی: 2 تیر 1397
Abstract:
The β-CD-DZ inclusion complex was prepared via freeze-drying method and characterizedby using various spectroscopic techniques. The phase solubility diagram and Job plot showed theformation of a soluble complex of AL type (1:1 stoichiometric IC) with improved solubility andstability. The thermodynamic parameters for the β-CD-DZ IC formation were determined and analyzedon basis of involved driving forces. The results showed the reaction process in mainly entropy drivenand endothermic that assigned the predominant role of hydrophobic interaction in the formation of β-CD-DZ complex. In conclusion, a comprehensive computational study has been done on formationprocess of β-CD-DZ IC using molecular docking methods. In case of β-CD-DZ IC, the results ofthermodynamic parameters, molecular docking confirmed stable complex formation between β-CDDZand also DZ included into a narrow site of inner cavity of β-CD.
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Authors
F Fateminasab
Department of Chemistry, University of Isfahan, Isfahan, ۸۱۷۴۶۷۳۴۴۱, Iran
A.K Bordbar
Department of Chemistry, University of Isfahan, Isfahan, ۸۱۷۴۶۷۳۴۴۱, Iran