Fluorescence study on the interaction between Nickel (II) Complex [Ni(bin)2OAC] and bovine serum albumin

The interaction of Nickel (II) Complex [Ni(bin)2OAC] and bovine serum albumin (BSA) was studied byfluorescence spectroscopy at room temperatures. The results revealed that Nickel (II) Complex [Ni(bin)2OAC] causedthe fluorescence quenching of BSA through a static quenching procedure. The binding constants (Kb ), and the numberof binding sites (n), were obtaind to be 1.11×106 and 1.040 at 298K, respectively. The primary binding pattern betweenNickel (II) Complex [Ni(bin)2OAC] and BSA was interpreted as hydrophobic interaction. in this study, it was decidedthat new water soluble compound of binicotinicacid ligand with formula [Ni(bin)2OAC],(bin= 2,2-bipyridine-3,3-dicarboxylic) will be designed and synthesized.

Keywords:

Bovine serum albumin (BSA) , Fluorescence spectra , Interaction , [Ni(bini)2 ](OAC)2