Association of HLA-DRB1*1501 allele with Multiple Sclerosis in North East and West of Iran
Publish place: 2nd International & 10th National Neurogenetic Congress,
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NGCMED10_036
تاریخ نمایه سازی: 16 تیر 1397
Abstract:
Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervoussystem (CNS) with a multi-factorial aetiology involving genetic factors.Among HLA class II histocompatibility antigens, HLA-DR plays a central role in the immune system through presentation ofpeptides derived from extracellular proteins to T helper cells. DRB1 beta chain is the most prevalent beta subunit of HLA-DR,which is a protein encoded by the HLA-DRB1 gene in human.Methods: Genomic DNA of 489 MS patients and 350 control samples from Mashhad and Ahvaz city of Iran was extracted andHLA-DRB1*1501 allele was determined by polymerase chain reaction (PCR). The frequency of HLA-DRB1*1501 in patientswas twice that of controls in this study (30.5% vs.17.3%). P value in Pearson Chi-squared test for HLA-DRB1*1501 wasstrongly significant (3.70 x 10-5) and Odds ratio was 2.095 (95% CI: 1.468-2.990). The results determined that HLADRB1*1501 strongly associated with MS disease.Discussion: HLA-DRB1*1501 is a predisposing factor for MS disease and DRB1*1501 allele is a similar predisposing allele inIranian and Western countries.
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Authors
Nasrin Moheghi
Department of Medical Genetics, faculty of medicine, St. George’s University of London, London, UK
Ali Walley
Department of Medical Genetics, faculty of medicine, St. George’s University of London, London, UK
R Sharifi
Department of Medical Genetics, faculty of medicine, St. George’s University of London, London, UK
K Nikkhah
Department of Neurology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran