Renoprotective effects of GABA on ischemia/reperfusion- induced renal injuryin hyperglycemic male and female rats

Introduction: Acute kidney injury (AKI) has been known as a complex clinicalcomplication in diabetic patients. The main cause of AKI is ischemia/reperfusion injury(IRI). This study was designed to investigate the protective effects of GABA on renal IRIin hyperglycemic female and male rats.Methods: Sixty STZ induced diabetic male and female Wistar rats were categorized in10 groups (5 female &5 male groups). Groups 1-3 in each gender received GABA for 3 days, and then were subjected to renal IRI .Group 4 in eachgender was subjected to renal IRI alone, and group 5 was subjected to surgical operationwithout renal IRI.24 hr after I/R injury, blood sample was obtained, and the animal weresacrificed for pathology investigation.Results: Renal IRI alone increased the serum blood urea nitrogen levels (BUN) andcreatinine (Cr), and kidney damage in both male and female rats significantly (P<0.05),however all doses of GABA decreased the serum BUN and Cr levels and tissue damagewhen compared with control group.Conclusion: From the results of this study it seems that GABA administration inhyperglycemic rats could decrease renal injury after an ischemia/reperfusion.

Keywords:

Ischemia , Reperfusion , Diabetes , GABA , Rat