IMMUNOLOGICAL EFFECT OF LACTOBACIILUS CASEI IN RAT WITH CANDIDA ALBICANS INFECTION

Background and Aim:Abstract: Immunological effect of Lactobaciilus casei in rat with Candida albicans infection Behnaz Haghayegh1, Mahboobeh Madani1* ,Fereshte Ghandehari1. 1. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran Objective: Probiotic organisms are claimed to offer several functional properties including stimulation of immune system. Candida albicans is the most common type of yeast infection that found in skin and mucous membranes such as mouth, intestinal tract and vagina. This study was undertaken to evaluate the humoral immunologic effect of Lactobaciilus casei in rat with Candida albicans infection.Methods:Material and Methods: 25 rats were randomly divided in 4 groups including two treatment, positive and negative groups. Treatment groups were recieved Lactobacillus casei within 20 days, every other day. In 11 day one treatment and positiv groups were received Candida albicans. Negative control received distilled water respectively. Blood samples were collected and serum proteins were determined.Results:Results: According to the results, gamma globulin was increased, whereas alfa and beta globulin were not affected. Conclusion: These findings suggested that Lactobaciilus casei has potential use as a functional food ingredient to improve the immune response agalst candida albicans.Conclusion:Conclusion: These findings suggested that Lactobaciilus casei has potential use as a functional food ingredient to improve the immune response against candida albicans.

Keywords:

Lactobacillus casei , Candida albicans , immune system , gamma globulin