The Role of Botulinum Toxin Type A in Treatment of Hypertrophic Scar Symptoms

Background: Hypertrophic scar lesion is the result of an increase in the activity of fibroblasts in skin ulcers. They might be painful or itchy and has beauty and functional complications for patient which may influence their quality of life. Now a day, varieties of methods are used but because of lesion recurrence, patients problems last. This study examines the effect of BTX-A on the improvement of hypertrophic scar as a new auxiliary method. Methods: In this double blind clinical trial, 45 patients with hypertrophic scar lesions were interfered from March 2016 to Jan 2018. Patient s lesion was randomly divided into two parts. In part one BTX-A with concentration of 200 units/ml and dose of 24 units/cm3 was injected and in another, normal saline was injected with the same volume. The injections were repeated monthly up to three times, and the patients were evaluated for erythema, pruritus, pain and satisfaction 6 months after the last injection. Results: A significant relationship exists in the reduction of erythema, pruritus (P = 0.000) and pain scores after the injection of BTX-A (P = 0.009). Conclusions: It seems that injection of botulinum toxin A in hypertrophic scar lesions as a new method, improves some of the symptoms of these lesions.

Keywords:

Hypertrophic Scar , Botulinum Toxin Type A , Pruritus , Erythema