Traumatic Endophthalmitis Prophylaxis with Oral Ciprofloxacin in Comparison to Intravenous Cephazolin / Gentamicin

Purpose: The aim of this study was to evaluate the efficacy and clinical outcome of oral ciprofloxacin vs. Intravenous Cephazolin / Gentamicin for prevention of endophthalmitis after penetrating ocular trauma Methods: This was a retrospective, single-center study, including all cases of penetrating ocular trauma seen in the Feiz hospital, a tertiary referral eye hospital in Isfahan, Iran, between 2011 and 2017. Data systemically recorded for each patient included clinical, ophthalmological, and demographic findings by a trained medical record abstractor or ophthalmologist reviewing patient records. Results: 645 patients in Cephazolin / Gentamicin and 273 patients in oral ciprofloxacin groups were included in the study. Our study showed that the incidence of endophthalmitis was not significantly different between two groups. (p-value: 0.463) in patients with either sharp or blunt penetrating ocular trauma. Conclusion: Oral ciprofloxacin as a prophylactic treatment could prevent post-traumatic Endophthalmitis as effective as injectable Cephazolin / Gentamicin. Due to easier consumption of oral ciprofloxacin and lower systemic complications, in all patients with penetrating eye trauma, oral administration of ciprofloxacin is preferable to intravenous or intra-muscular types of antibiotics to reduce the risk of post-traumaticEndophthalmitis.