Clinical and microbiological predictors of post prostate biopsy infection

Background: To research on clinical and bacterial risk factors and their relationship with post-prostate biopsy infection (PBI). Methods: In this prospective cohort study, rectal swabs were collected from 158 men prior to prostate biopsy and cultured selectively for identify ciprofloxacin-resistant (FQ-R) gram-negative bacteria. The patient characteristics, phylogenetic background, sequence typing and pulsed field gel electrophoresis (PFGE) pattern were compared in two groups of FQ-R E. coli rectal and clinical isolates. Results: In total, 73 (46.2%) patients had a positive rectal culture for FQ-R gram-negative bacteria (95.9% E. coli). PBI was observed in 20 (12.5%) cases; nearly all of these subjects were FQ-R-colonized. (17/73 [24%] vs. 3/85 [3.5%]; P<0.001). FQ-R colonization, diabetes, hospitalization and UTI were independent risk factors that increased the rate of PBI (All P<0.05). Despite the increase in infections among patients colonized with strains of E. coli ST131, its prevalence was almost statistically significant between colonized and infected groups[OR:3.269, 95% CI:0.942-11.448;P =.06].The PFGE patterns and antimicrobial susceptibility profiles of rectal and clinical isolates in 13 patients were similar which is remarkably important and informative. Conclusions: The most PBIs originate from FQ-R E. Coli rectal colonization. Rectal culture screening and assessment of clinical risk factors can predict the incidence of PBI in patients.

Clinical and microbiological predictors of post prostate biopsy infection Keywords:

Biopsy , Drug resistance , Infection , Prostate