Correlation between the extent of coronary atherosclerosis and Serum/ Dietary Total Antioxidant Capacity

Introduction: Oxidant stress in the cardiovascular system may occur when antioxidant capacity is insufficient to reduce reactive oxygen species and other free radicals. The possible involvement of oxidative damage in the progression of atherosclerosis has been suggested.We investigated the relationship between severity of coronary artery disease (CAD) and serum antioxidant status by measuring the serum total antioxidant capacity (sTAC).Materials and Methods: In this cross-sectional study a total of 160 consecutive patients who were diagnosed as CAD+ by coronary angiography. -At baseline, we collected information about age, job, educational level, marital status, smoking, medications, present and past medical history, family history of CAD by filling the demographic questionnaire. Height, weight were measured by standard tools.Dietary intakes were assessed by a semi-quantitative food frequency questionnaire (FFQ) with 168 items. Dietary TAC (Total Antioxidant Capacity) was obtained according to United States Department of Agriculture (USDA) Database for oxygen radical absorbance capacity (ORAC).-After an overnight fasting of 10 h, venous blood samples from participants were collected for Total Antioxidant Capacity of serum.- The severity of CAD was expressed as the sum of the Gensini scores for each lesion. Patients’ demographic variables, medical histories, and clinical features, as well as in-hospital major adverse events, were obtained from the medical reports.Results : The mean age and BMI of patients were 60.53 (±11.227)and 25.887(± 3.53).Mean (±SD) of Gensini score, sTAC, dietary TAC were 36.389 (±33.041),4.4368(±2.35), and 14782(±2959.8) respectively. The gensini score had an inverse significant correlation with dietary TAC.The sTAC values were significantly different between three tertiles of dietary total antioxidant capacity (p<0.05).sTAC had a significant relationship with dietary total antioxidant capacity (p<0.05). Gensini scores showed a significant difference between tertile groups of dietary total antioxidant capacity (p<0.0001).Conclusion: The severity of coronary atherosclerosis calculated by Gensini score was negatively correlated with antioxidant status.Dietary intake of antioxidant resources of food may have an important role against oxidative stress by increasing serum Total Antioxidant Capacity (sTAC), so increasing consumption of fruits and vegetable is emphasized.

Keywords:

sTAC , dietary TAC , Gensini Score , nutrition , CAD