The investigation of the synthesis of 4-(2H-tetrazol-5-yl)pyridine
Publish place: The Regional Chemistry Conference
Publish Year: 1389
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MIAUCHEMISTRY01_080
تاریخ نمایه سازی: 18 اسفند 1397
Abstract:
Although the tetrazole system rarely occurs in nature, it has been an increasingly important pharmacopoeia in medical chemistry because of its metabolic stability and unique structural and electronic features [1]. In this research work, we synthesized some new compounds of alkyl tetrazoles. Therefore, isonicotinaldehde (1) in reaction with NH2OH was converted to isonicotinaldehyde oxime (2). The obtained compound was dehydrated by acetic anhydride to give isonicotinonitrile (3). Then, 4-(2H-tetrazol-5-yl)pyridine (4) was prepared by [2+3] cycloaddition reaction between (3) and NaN3. The structure of all the synthesized compounds were characterized and confirmed by FT-IR and NMR spectroscopy techniques.
Authors
L. Edjlali
Department of Applied Chemistry, Faculty of Science, Islamic Azad University, Tabriz Branch, P.O.Box ۱۶۵۵, Tabriz, Iran
A. Sepehryan
Islamic Azad University, Ahar Branch
Sh Samadzadeh
Islamic Azad University, Ahar Branch
Y Soleymani
Department of Applied Chemistry, Faculty of Science, Islamic Azad University, Tabriz Branch, P.O.Box ۱۶۵۵, Tabriz, Iran