Background: The prevalence of migraine headaches significantly increased ingirls after menarche. This indicated that there is a closely relation betweenhormonal changes especially the estrogen level with migraine headaches.Objectives: The aim of this work was to determine the frequency of migraineand its associated factors in medical students affected with premenstrualsyndrome (PMS).Materials and Methods: This cross-sectional study was done on 218 ofmedical students (between 18 to 30 years old) in Mashhad in the North-East ofIran from March 2015 to March 2016. Premenstrual syndrome was confirmedby Premenstrual Symptoms Screening Tool (PSST). Migraine headache wasdetermined according to International
Headache Society (HIS) criteria. Thefrequency of menstrual migraine and its associated factors includingeducational degree, life style, marital status, menstrual regularity, family historyand type of migraine were determined among the participants with PMS. Dataanalyze was performed by SPSS 21 and STATISTICA 10.Results: Of 218 students with premenstrual syndrome, 32 persons (14.7%) hadmigraine headache. 84.4% of migraines were without aura and the mean attacksper months were 4.34±1.93. The most prevalence of migraine observed instudents with 22.09±2.44 years old, intern students (16.1%), Mariel students(20%), students with irregular menstruation (26.3%), students with positivefamily history (36.5%) and students which lived in dorm (26.1%).Conclusion: According to our results, the prevalence of migraine in studentswith PMS is in the range of 14.7%. Therefore, it is recommended that womensuffering from PMS be evaluated for migraine based on diagnostic criteria ofHIS.