Non-adherence to Disease-Modifying Treatments in Patients with Multiple Sclerosis
Publish place: Caspian Journal of Neurological Sciences، Vol: 3، Issue: 10
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CJNS-3-10_002
تاریخ نمایه سازی: 18 اسفند 1397
Abstract:
Background: Multiple Sclerosis (MS) is a debilitating disease of the centralnervous system. Usually, long-term MS medications are injectedintramuscularly or subcutaneously, making them intolerable for many MSpatients.Objectives: In the present study, the rate and the causes of non-adherence toMS disease-modifying drugs (DMDs) were assessed in patients with MS.Materials and Methods: Two hundred and three MS patients of Guilan MSSociety were interviewed demographic and clinical data of the patients werecollected.Results: Among the 203 patients, 73.9% were female. The mean±SD age ofthe patients was 32.47±9.15. Non-adherence to DMDs was due to side effects(21.7%) and requests of the families (21.7%) or ineffectiveness (17.4%).Significant association was seen between the non-adherence to DMDs andgender (p=0.015) and relapses (p=0.021).Conclusion: The evidence from the present study suggests that there is a highrate of non-adherence to DMDs in MS patients in Guilan.
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Authors
Seyed-Ali Roudbary
MD, Neurology Department, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences,Rasht, Iran
Shahrokh Yousefzadeh-Chabok
MD, Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Hamid Behzadnia
MD, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of MedicalSciences, Rasht, Iran
Babak Bakhshayesh-Eghbali
MD, Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine,Guilan University of Medical Sciences, Rasht, Iran