Non-adherence to Disease-Modifying Treatments in Patients with Multiple Sclerosis

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CJNS-3-10_002

تاریخ نمایه سازی: 18 اسفند 1397

Abstract:

Background: Multiple Sclerosis (MS) is a debilitating disease of the centralnervous system. Usually, long-term MS medications are injectedintramuscularly or subcutaneously, making them intolerable for many MSpatients.Objectives: In the present study, the rate and the causes of non-adherence toMS disease-modifying drugs (DMDs) were assessed in patients with MS.Materials and Methods: Two hundred and three MS patients of Guilan MSSociety were interviewed demographic and clinical data of the patients werecollected.Results: Among the 203 patients, 73.9% were female. The mean±SD age ofthe patients was 32.47±9.15. Non-adherence to DMDs was due to side effects(21.7%) and requests of the families (21.7%) or ineffectiveness (17.4%).Significant association was seen between the non-adherence to DMDs andgender (p=0.015) and relapses (p=0.021).Conclusion: The evidence from the present study suggests that there is a highrate of non-adherence to DMDs in MS patients in Guilan.

Authors

Seyed-Ali Roudbary

MD, Neurology Department, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences,Rasht, Iran

Shahrokh Yousefzadeh-Chabok

MD, Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Hamid Behzadnia

MD, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of MedicalSciences, Rasht, Iran

Babak Bakhshayesh-Eghbali

MD, Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine,Guilan University of Medical Sciences, Rasht, Iran