Synthesis of highly substituted dihydro-2-oxopyrroles using Fe3O4@nano-cellulose-OPO3H as a novel bio-based magnetic nanocatalyst

Economically importance and environmentally benign features of magnetic nanoparticles (MNPs) have put them under chemical spotlight [1]. Cellulose, as a renewable and naturally abundant biopolymer, is one of the most ideal coating layers for Fe3O4 NPs because it not only stabilizes the nanoparticles in solution but also enjoys free OH groups for functionalization purposes [2].2-Oxodihydropyrroles as an important class of heterocycle compounds have wide biological activities such as herbicidal, antitumor, antibiotic, antimalarial and anti-HIV [3]. In this study, Fe3O4@nano-cellulose-OPO3H (Fe3O4@NCs-PA) was synthesized as a new magnetic bio-based nanocatalyst and characterized by FT-IR, FESEM, XRD, TGA, VSM, EDX, XRF and BET. This catalyst was successfully applied to the synthesis of 2-oxo dihydropyrrole derivatives via the four-component reaction of dialkylacetylenedicarboxylate, aldehyde, and amines.The present procedure is a green and environmental friendly approach that offers many advantages including high yield, easy work-up, simple recovery and reusability of the catalyst.