Efficiet one-pot synthesis of pyrazoles catalyzed by nono particles Graphine/iron oxid(hematite), Hollow zine ferrite nanosphere, Au nano particles using green chemistry

Pyrazoles are of significant synthetic targets in organic and pharmaceutical chemistry because of pyrazole motif generally acting as a core framework in numerous biologically active compounds [1–3]. As a part of our continuing effort towards the development of useful synthetic methodologies, here in we report an efficient process for synthesis of various pyrazoles, in the reaction of different 1,3-dicarbonyl compounds with hydrazines using nano particles Graphine/iron oxid(hematite), Hollow zine ferrite nanosphere, Au nano particles, as the catalyst solvent-free conditions have also been reported (Scheme1). This extensive application of heterogeneous catalysts in synthetic organic chemistry can make the synthetic process more efficient from both environmental and economic point of view and used-catalyst can be easily recycled. Performance of reaction under solvent-free conditions, short reaction times, and high returns are the benefits of this research work. The structure of the products was investigated by IR and 1H-NMR.