Host-guest complex of curcumin with beta-cyclodextrin and its antioxidant activity

This study was to synthesize and characterization the host-guest complex of curcumin with β-cyclodextrin (β-CD) which has antioxidanting activity property. The host-guest interaction of curcumin with β-CD in order to complexation drug in β-CD were investigated at 25°C. The interactions host-guest complex was characterized by fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) spectroscopies. The solution of curcumin is prepared in 0.06 mM concentration with methanol. Curcumin is the phytochemical that gives yellow color to turmeric [1]. UV-vis spectra were analysised of curcumin/β-CD complex at maximum wavelength 418 nm of curcumin. The formation constant was calculated by using a modified Benesi-Hildebrand equation to big number of 1.8 × 105 M-1. The stoichiometry of host-guest complex was found by using of Job s plot to be 1:1 for β-CD with curcumin.Curcumin is reported to have a number of pharmacological activities including antioxidant, HIV antiproteases activity, anti-inflammatory, analgesic, anticancer, etc [2]. The aim of research has the antioxidant activity of curcumin and its host-guest complex were determined by the scavenging of stable radical 2,2՜-diphenyl-1-picrylhydrazyl (DPPH˙)[3]. Kinetic studies for remove DPPH˙ in presence curcumin and curcumin/β-CD complex were done at amount of 95%. The results obtained indicated that the curcumin/β-CD host-guest complex was the most reactive than its free form into antioxidant activity. Therefore most common pharmaceutical application of β-CD is to enhance curcumin solubility in aqueous solutions