Synthesis of functionalized trifluoro methylated ketenimines and 1-azabuta dienes via isocyanide based multicomponent reactions

Trifluoromethylated compounds play a significant role in life sciences which have many remarkable functions and numerous properties such as agrochemicals and pharmaceuticals activities [1, 2]. On the other hand, multi-component reactions are a one of the best method for synthesis of highly functionalized fluoranitated and stableketenimines and aza-butadiens derivatives and they have many applications such as: nucleophilic additions, radical additions, cycloaddition reactions [3].In this research a series of novel trifluoromethylated ketenimines and 1-aza butadiene derivatives were synthesized via a one-pot multicomponent reactions of alkyl isocyanides, ethyl 4, 4,4-trifluoro butynoate and quinolin-4(1H)-one in good yields (scheme 1).The structures of all products were clearly established by IR, NMR (1H, 13C and 19F)and mass spectroscopy. The present method carries the advantage that not only the reaction is performed under neutral conditions, but also the starting materials and reagents can be mixed without any activation or modification