Can pregnancy induce relapse in systemic lupus erythematosus (SLE)
Publish place: Rheumatology Research، Vol: 1، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RHRE-1-1_005
تاریخ نمایه سازی: 1 خرداد 1398
Abstract:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which mostly affects women of reproductive age. We evaluated the impact of pregnancy on maternal/fetal health, the pattern of organ involvements and the fare-up risk. In a retrospective study we studied the thirty-year medical records of patients between 1976-2005. Maternal, neonatal and infantile health data was retrieved. Incidence of flare-ups, pattern of organ involvements and the outcome of pregnancy was analyzed. We studied 155 pregnancies in 129 SLE patients. Mean age of patients was 27.0 ± 5.5 years (range, 16-44). Thirty one cases (20.2%) experienced flares in the course of pregnancy. During pregnancy, SLE disease activity index (SLEDAI) score increased in 92 (59.3%) patients (median increase = 6 scores). On the other hand, 38 cases (24.5%) SLEDAI score remained unaltered and in 25 cases (16.1%) SLEDAI score decreased (median decrease = 1). Mean SLEDAI during pregnancy were significantly higher than preconceptional scores (P-value = 0.002).Term delivery was more common in quiescent SLE (54.2% vs. 34.6%, P-value = 0.04). Number of therapeutic abortions was higher in active SLE (38.5% vs. 10.2% P-value = 0.003). In this study increased SLEDAI and flare-up episodes were observed during pregnancy. However the majority of cases did not face major fetal or maternal complications.
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Authors
Gilda Parastandechehr
Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
Seyedeh Tahereh Faezi
Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
Pedram Paragomi
Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
Maassoumeh Akhlaghi
Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
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