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Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice

Publish Year: 1398
Type: Journal paper
Language: English
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JR_AJP-9-3_006

Index date: 28 May 2019

Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice abstract

Objective: The purpose of this study was to investigate the protective and therapeutic effects of aqueous extract of P. atlantica gum on an experimental asthma in BALB/c mice. Materials and Methods: Aqueous extract of dried and milled P. atlantica gum was assemble andevaluate by GC-MS.  In order to investigate the effect of P. atlantica gum extract on cellular and pathological aspects of asthma, 60 BALB/c mice were divided into six groups as: negative control, asthmatic group, asthmatic group receiving dexamethasone (1mg/kg; intraperitoneal (IP)) and three asthmatic groups receiving different concentrations of the extract (100, 200 and 400 mg/kg, orally) from the beginning of the study and continued for 84 days. The examined parameters included cell population, IgE antibody production, levels of IL-4, IL-5, TGF-β, INF-γ, IL-10, and IL-17 cytokines, and lung tissue damage. Results: Regardless of the dose, aqueous extract of P. atlantica gum, caused significant decrease in the number of BALF eosinophilic cells and levels of anti-ovalbumin IgE, IL-4, IL-5 and IL-17 cytokine levels, as well as pathologic damage of the lung tissue. In addition, the amount of anti-inflammatory IL-10, TGF-β, and INF-γ Th1 cytokines significantly increased in the extract-treated groups compared to the asthmatic and dexamethasone-treated groups. Moreover, IFN-γ/IL-4 ratio significantly increased in a dose-dependent manner compared to the un-treated asthma group. Conclusion: The aqueous extract of P. atlantica gum can be considered as a potent anti-inflammatory and immunomodulatory compound and may be used as a natural compound for treatment of immune system disorders.

Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice Keywords:

Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice authors

Zaynab Shakrami

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran|Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

hadi Esmaeili Gouvarchin ghaleh

Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

bahman mansouri motlagh

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali Sheikhian

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences.

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Esmaili Gourvarchin Galeh H, Abtahi Froushani SM, Afzale Ahangaran N, ...
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, ...
Haghdoost F, Baradaran Mahdavi MM, Zandifari A, Sanei MH, Zolfaghari ...
Hansbro PM, Kaiko GE, Foster PS. 2011. Cytokine/anti-cytokine therapy- novel ...
Hosseini F, AdlgostarA and Sharifnia F. 2013. Antibacterial activity of ...
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Levy ML, Hardwell A, McKnight E, Holmes J. 2013. Asthma ...
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Newcomb DC, Peebles RS. 2013. Th17-mediated inflammation in asthma.  Curr ...
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Sharifi MS, Hazell SL. 2011. GC-MS analysis and antimicrobial activity ...
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Tripathi P, Nair S, Arora N. 2013. Supplementation of antioxidants ...
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