Comparison of L-FABP concentration in obese and lean men after one bout intensive aerobic exercise

Introduction: Liver fatty acid binding protein (L-AFBP) is a novel biomarker of liver disease. Liver enzymes levels are higher in the obese than the lean people; however the effect of intensive aerobic exercise (IAE) on liver enzymes in the obese and the lean people not well known. Thus the aim of the present study was to comparison of L-FABP concentration in the obese and lean men after one bout IAE. Material & Methods: Nine sedentary obese men (BMI: 33.7 ± 2.1 kg/m2; ± SD) and nine sedentary lean men (BMI: 17.6 ± 1.6 kg/m2; ± SD) volunteered to participate in this study. All the subjects were performed the Bruce test as the intensive aerobic exercise. Blood samples were taken before and immediately after the IAE. Results: The results showed that alanine aminotransferase (ALT) was higher in obese group than the lean group at the baseline (P<0.05). L-AFBP decreased and ALT and aspartate aminotransferase (AST) increased after the IAE in the both groups (P<0.05). By comparison, the results indicated that the increase of ALT was higher in the obese group than the lean group (P<0.05); however, for L-AFBP and AST no significant differences were observed between two groups. Conclusions: One bout IAE increases AST and ALT and decreases L-AFBP in the obese men same as lean men.

Comparison of L-FABP concentration in obese and lean men after one bout intensive aerobic exercise Keywords:

Liver function , L-AFBP , AST , ALT