The Correlation between Glucose and Lipid Biomarkers Variations with biometric characteristics and Intraocular Pressure Changes during Ramadan Fasting

Introduction: The aim of present study was to assess the correlation between glucose and lipid biomarkers variations with biometric characteristics and intraocular pressure changes following Ramadan fasting. Methods: A total of 100 healthy fasting volunteers were enrolled in the study. Of them, 89 subjects completed the study with respect to inclusion and exclusion criteria. Right eye ocular axial length and anterior chamber depth were determined using the IOLMaster, (Carl Zeiss Meditec, Jena, Germany). Following that, intraocular pressure of right eye was measured using a non-contact tonometer (Topcon, Computerized Tonometer CT-1/CT-1P, Tokyo, Japan). Blood samples were taken from all the participants and concentrations of the biomarkers, including Fast blood sugar, Triglyceride, Cholesterol, High-density lipoprotein and Low-density lipoprotein were measured using the Hitachi 717 analyzer (Hitachi, Tokyo, Japan). All assessments were obtained one week before and after Ramadan. Results:  Of 89 healthy Muslims who complete the study, 51 were men (mean age: 35.51±8.94 years) and 38 were women mean age: 34.26±9.41 years).The results indicated no significant relationship between the axial length with glucose and lipid biomarkers variations in the fasting individuals. The assessment of result showed only a slight correlation between anterior chamber depth and High-density lipoprotein changes during Ramadan, however, this was not statistically significant. Also, findings revealed only a slight correlation between intraocular pressure and cholesterol changes in healthy fasting individuals, however, this was not statistically significant. Conclusion: Our study revealed that ocular parameters changes during Ramadan fasting is probably independent to variation levels of glucose and lipid biomarkers.  

Keywords:

Biomarkers , Axial length , Anterior chamber depth , Intraocular pressure