رابطه بین گرلین و استروژن در تخمدان گوسفندان آبستن
Publish place: Iranian Journal of Veterinary Medicine، Vol: 10، Issue: 2
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-10-2_008
تاریخ نمایه سازی: 12 تیر 1398
Abstract:
Background:Ghrelin, an endogenous ligand for the growthsecretagogue receptor is predominantly produced in the stomach and anexpression of ghrelin has recently been identified in placenta and ovary. OBJECTIVES: Therefore, we decited to measure ovarian ghrelin as quantitative andevaluate the correlation between ghrelin and estrogen during second half ofovine pregnancy. METHODS: The ovarian samples were collected from 40pregnant sheep in 3, 3.5, 4, 4.5 and 5 months of pregnancy in a local abattoir.Follicles and active corpora lutea (CL) were dissected from surroundingtissues, separately. The samples were homogenized with phosphate buffer (0.1 M,pH=7.4) on liquid nitrogen to provide fluid samples. Ghrelin and estrogenconcentrations were measured by ELISA method and expressed as milligram (mg)and picogram (pg) per mg of tissue protein, respectively. RESULTS:There was a linear correlation between ghrelin and estrogen in ovarian follicles(r=0.97 and p=0.004), but not in CL. Follicular ghrelin significantly increasedin 4, 4.5 and 5 months (p<0.001) but CL ghrelin significantly decreased inthe 4.5 month of ovine pregnancy (p<0.01). Estrogen concentration was alsosignificantly higher in 4-5 months of pregnancy in ovarian follicles(p<0.001) but potent CL indicated higher estrogen level only in the 5thmonth of pregnancy (p<0.001). CONCLUSIONS:These results emphasize the role of ghrelin inthe reproductive system and open a new window to future studies
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Authors
Ali Sookhtehzari
Department of Clinical Sciences, School of Veterinary Medicine, Lorestan University, P. O. Box: ۴۶۵, Khorramabad, Iran
Masoud Alirezaei
Division of Biochemistry, School of Veterinary Medicine, Lorestan University, P. O. Box: ۴۶۵, Khorram Abad, Iran
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