Superiority of Buprenorphine over Suboxone in Preventing Addiction Relapse in Opioid Addicts under Maintenance Therapy: A Double-Blind Clinical Trial
Publish place: Asia Pacific Journal of Medical Toxicology، Vol: 7، Issue: 1
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_PJMT-7-1_001
تاریخ نمایه سازی: 17 تیر 1398
Abstract:
Background: In maintenance therapy for opioid addiction, to reduce the risk of buprenorphine (BUP) abuse, the combination of BUP and naloxone (NX) has been developed and is commercially available as suboxone (BUP/NX). This study was designed to compare addiction relapse frequency in patients receiving BUP and BUP/NX as maintenance therapy. Methods: In this double-blind clinical trial with cross over design, 100 opioid abusers were randomly assigned to two treatment groups to receive either BUP or BUP/NX. After three months, without a time-out period, subjects undertook treatment with the other drug. The subjects were screened weekly for urinary morphine. Results: In each of the study arms, when the patients were given BUP/NX, the number of relapses was significantly higher compared to when they received BUP (0.13±0.24 vs. 0.04±0.09, P = 0.001). If participants’ age was taken into account, the number of relapses was significantly higher when BUP/NX was given in age groups of 31 to 40 years and over 50 years (P < 0.05). The length of addiction had also a significant impact on the number of relapses, i.e., patients with over 10-year history of addiction had higher number of relapses if they were given BUP/NX compared with BUP (P < 0.05). Conclusion:BUP seems to be more effective than BUP/NX in preventing addiction relapse in opioid abusers under maintenance treatment.
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Authors
Zahra Shojaei Ghalehney
Addiction Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Shahram Ilbeigi
Addiction Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid Reza Arshadi
Department of Psychiatry, Islamic Azad University of Mashhad, ۲۲-Bahman University Hospital, Mashhad, Iran
Reza Afshari
Environmental Health Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada
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