Association between PAPP-A and placental thickness
Publish place: 1st international congress of perinatology 7th national congress of perinatology & neonatology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
PNMED07_060
تاریخ نمایه سازی: 18 تیر 1398
Abstract:
Background:Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta.Objective:The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester.Materials and Methods:In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A ≤0.8 MOM were in exposed and others who had PAPP-A > 0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50% of placental length.Results:Of 187 patients, 87 patients had PAPP-A > 0.8 and 93 patients had PAPP-A ≤0.8. Women with low levels of PAPP-A in the first trimester, had an increased incidence placental thickness of 34.4%,whereas another group had about 15% (p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for placental thickness detection (71.1% and 54.8%, respectively. Conclusion:Our study showed that serum level of PAPP-A generally was low (≤0.8) in women with a thick placenta (> 4 cm or > 50% of placental length). The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta.
Authors
Elaheh Mesdaghinia
Kashan University of Medical Sciences, Kashan, Iran
Mitra Behrashi
Kashan University of Medical Sciences, Kashan, Iran
Arezoo Saeidi
Kashan University of Medical Sciences, Kashan, Iran
Masoomeh Abedzadeh Kalahroodi
Truma Medical Center, Kashan University of Medical Sciences, Kashan, Iran