Comparison the Effect of Placenta Membrane Using Alone or With Silver Sulfadiazine in Treatment of Burns in Rats
Publish place: 20th Annual Conference and 3rd International Conference on Pathology and Laboratory Medicine
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ACPLMED20_032
تاریخ نمایه سازی: 29 تیر 1398
Abstract:
Aims: Silver sulfadiazine is widely used for burning wound. Studies have shown that, dressing wounds with placental membrane can accelerate their healing. Our objective was to evaluate the recovery of second-degree burns in male rats that treated with topical Silver sulfadiazine-impregnated placental amniotic membrane. Materials & Methods: In this experimental study, 64 male rats were divided into 4 similar groups. In all rats, the second degree burn was induced under general anesthesia. Wound dressing in the first group (control) included simple dressing, but amniotic membrane in second group, and Silver sulfadiazine in third group and in the fourth group it was Silver sulfadiazine impregnated amniotic membrane. At the end of the 7th, 14th, 21st and 28th day, under the general anesthesia, the tissue biopsies were taken from burns and microscopic evaluation was done. Data were analyzed statistically using ANOVA and P less than 0.05 was considered as significant. Findings: In treated groups, the PMN leukocyte count was significantly lower than control (p<0.001), also the amount of granular formation and its organization, the number of fibroblasts, and the rate of wound healing were greater than control (p<0.001). There was no significant difference in measured parameters between the 3 treatment groups. Conclusion: Considering the biological effects of the ammonium membrane, it is recommended to use it as an effective dressing method to accelerate burn wound healing.
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Authors
Fatemeh Samii rad
Pathologist, Associate Professor, faculty of Medicine University of Qazvin University of Medical Sciences
Mehri Kalhor
PhD student of Reproductive health of Tarbiat Modarres University, Kowsar Hospital of Qazvin University of Medical Sciences
Mohammad Sofiabadi
M. PhD, Cellular & Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Mohammad Reza Maleki
Assistant Professor of Pediatrics School of Medicine Qazvin university of medical sciences