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Clinical outcomes of IMSI and embryo morphokinetics in patients with male factor infertility

Publish Year: 1398
Type: Conference paper
Language: English
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RMED08_045

Index date: 12 August 2019

Clinical outcomes of IMSI and embryo morphokinetics in patients with male factor infertility abstract

Background: Sperm morphology and fine integrity of sperm nuclei are positively associated with fertilization, implantation and clinical pregnancy rates.Objective: The objective was to evaluate the effect of IMSI on the morohokinetics of early developmental events of embryos and clinical outcomes in patients with different etiologies of male factor infertility.Materials and Methods: The study population consisted of 75 couples involved in the IMSI program with different etiologies of male infertility: (astenozospermia (AS) n=7, oligoastenotratozospermia (OAT) n=26, astenotratozospermia (AT) n=20, and tratozospermia (T) n=22) patients. The sperm selections were done according to MSOME criteria by Cassuto method, MII oocytes were injected and the zygotes were cultured in time-lapse monitoring system (TLM) for 3 days. The main outcome measures were embryo kinetics and clinical outcomes.Results: 320 embryos were developed and assessed using TLM. 90 embryos were assessed from OAT, 30 embryos from AS, 92 embryos from AT and 108 embryos from T patients. Data showed, that the rate of cleavage abnormalities and embryo morphokinetic timing had no significant differences between them (p> 0.05). Among the transferred embryos in different patients, the rates of chemical pregnancy and implantation were respectively higher in OAT patients (37.8% and 38.2%) and the clinical pregnancy and live birth rates were insignificantly higher in Tratozospermia patients (32% and 32%) when compared with other patient groups.Conclusion: Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and tratozospermia patients.

Clinical outcomes of IMSI and embryo morphokinetics in patients with male factor infertility Keywords:

Clinical outcomes of IMSI and embryo morphokinetics in patients with male factor infertility authors

E Mangoli

Department of Reproductive Biology, Research and Clinical Center for Infertility, Yazd Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

MA Khalili

Department of Reproductive Biology, Research and Clinical Center for Infertility, Yazd Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

AR Talebi

Department of Reproductive Biology, Research and Clinical Center for Infertility, Yazd Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

A Agha-Rahimi

Department of Reproductive Biology, Research and Clinical Center for Infertility, Yazd Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran