Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_AJP-2-4_004

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.).  Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures. 

Authors

Esmaeal Tamaddonfard

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran

Amir Erfanparast

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran

Nasrin Hamzeh-Gooshchi

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran

Shahnaz Yousofizadeh

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia ۵۷۱۵۳-۱۱۷۷, I.R. Iran