Neuro-pharmacological effects of Crinum zeylanicum in mice
Publish place: Avicenna Journal of Phytomedicine، Vol: 2، Issue: 3
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJP-2-3_008
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system.
Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance.
Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod.
Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
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Authors
Adeniyi Yahaya Tijani
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
Oluwakanyinsola Adeola Salawu
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
Good-luck Jaiyeoba
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
Joseph Akponso Anuka
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria