An advection-diffusion multi-layer porous model for stent drug delivery in coronary arteries

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
View: 417

This Paper With 18 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_JCARME-9-1_001

تاریخ نمایه سازی: 1 مهر 1398

Abstract:

Arterial drug concentration distribution determines local toxicity. The safety issues dealt with Drug-Eluting Stents (DESs) reveal the needs for investigation about the effective factors contributing to fluctuations in arterial drug uptake. The current study focused on the importance of hypertension as an important and controversial risk factor among researchers on the efficacy of Heparin-Eluting Stents (HES). For this purpose, the effect of blood pressure is systematically investigated in certain cardiac cycle modes. A comprehensive study is conducted on two classes, pulsatile (time-dependent), to have a more realistic simulation, and non-pulsatile (time-independent) blood flow, each one in four modes. The governing equations applied to drug release dynamics are obtained based on porous media theory. The equations are solved numerically using Finite Volume Method (FVM). Results reveal that there is a significant difference when the plasma flow considered and when it is neglected (regardless of time dependency). Moreover, the concentration level is more decreased in pulsatile blood flow rather than the non-pulsatile blood flow, although the penetration depth for pressure and concentration are nearly 20% and 5% of the wall thickness, respectively. In other words, the mass experienced by the arterial wall is lower in pulsatile blood flow in comparison to non-pulsatile blood flow. As a consequence, the risk of toxicity is declined as the blood pressure increases. Also, it can be seen that the polymer is diffusion-dominated so that no significant changes in the release characteristics are observed in the presence of the plasma filtration.

Authors

Seyed Masoud Vahedi

Faculty of Mechanical Engineering, Semnan University, Semnan

Mohammad Sadegh Valipour

Faculty of Mechanical Engineering, Semnan University

Filippo de Monte

Department of Industrial and Information Engineering and Economics, University of L Aquila

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • B.M. O’Connell, E.M. Cunnane, W.J. Denny, G.T. Carroll and M.T. ...
  • T. Shazly, V.B. Kolachalama, J. Ferdous, J.P. Oberhauser, S. Hossainy ...
  • C. Yang, and H.M. Burt, Drug-eluting stents: factors governing local ...
  • R. Mongrain, I. Faik, R.L. Leask, J. RodĆ and O.F. ...
  • F. Alfonso, R.A. Byrne, F. Rivero and A. Kastrati, Current ...
  • A. Kastrati, A. Dibra, C. Spaulding, G.J. Laarman, M. Menichelli, ...
  • C. Spaulding, P. Henry, E. Teiger, K. Beatt, E. Bramucci, ...
  • G.J. Laarman, M.J. Suttorp, M.T. Dirksen, L. van Heerebeek, F. ...
  • F. Rikhtegar, E.R. Edelman, U. Olgac, D. Poulikakos and V. ...
  • F. Bozsak, J.M. Chomaz and A.I. Barakat, Modeling the transport ...
  • D.M. Martin and F.J. Boyle, Drug-eluting stents for coronary artery ...
  • S. McGinty and G. Pontrelli, A general model of coupled ...
  • B.M. O’Connell and M.T. Walsh, Demonstrating the influence of compression ...
  • G. Pontrelli and F. de Monte, Mass diffusion through two-layer ...
  • G. Pontrelli and F. de Monte, Modeling of mass dynamics ...
  • C.J. Creel, M.A. Lovich and E.R. Edelman, Arterial paclitaxel distribution ...
  • C.W. Hwang, D. Wu and E.R. Edelman, Physiological transport forces ...
  • G. Pontrelli, A. Di Mascio and F. de Monte, Local ...
  • P. Zunino, C. D’Angelo, L. Petrini, C. Vergara, C. Capelli ...
  • B. Balakrishnan, J.F. Dooley, G. Kopia and E.R. Edelman, Intravascular ...
  • P. Zunino, Multidimensional pharmacokinetic models applied to the design of ...
  • F. Migliavacca, F. Gervaso, M. Prosi, P. Zunino, S. Minisini, ...
  • E. Cutrì, P. Zunino, S. Morlacchi, C. Chiastra and F. ...
  • C. D Angelo and P. Zunino, Robust numerical approximation of ...
  • S. Chung and K. Vafai, Effect of the fluid–structure interactions ...
  • V.B. Kolachalama, A.R. Tzafriri, D.Y. Arifin and E.R. Edelman, Luminal ...
  • B. Balakrishnan, A.R. Tzafriri, P. Seifert, A. Groothuis, C. Rogers ...
  • V.B. Kolachalama, E.G. Levine and E.R. Edelman, Luminal flow amplifies ...
  • S. McGinty, S. McKee, C. McCormick and M. Wheel, Release ...
  • A. Borghi, E. Foa, R. Balossino, F. Migliavacca and G. ...
  • G. Vairo, M. Cioffi, R. Cottone, G. Dubini and F. ...
  • X. Zhu, D.W. Pack and R.D. Braatz, Modelling intravascular delivery ...
  • J.K. Chesnutt and H.C. Han, Simulation of the microscopic process ...
  • S. Wang and K. Vafai, Analysis of low density lipoprotein ...
  • S. Chung and K. Vafai, Low-density lipoprotein transport within a ...
  • S. Chung and K. Vafai, Mechanobiology of low-density lipoprotein transport ...
  • N. Zhang, P. Zhang, W. Kang, D. Bluestein and Y. ...
  • N. Yang and K. Vafai, Low-density lipoprotein (LDL) transport in ...
  • F. Khalighi, A. Ahmadi and A. Keramat, Water hammer simulation ...
  • Suhas V.Patankar, Numerical Heat Transfer and Fluid Flow, McGraw Hill, ...
  • M. Alemi and R. Maia, A comparative study between two ...
  • نمایش کامل مراجع