Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes
Publish place: Iranian Chemical Communication، Vol: 6، Issue: 3
Publish Year: 1396
Type: Journal paper
Language: English
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JR_ICC-6-3_001
Index date: 24 September 2019
Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes abstract
This work described a simple and efficient method for the synthesis of 1-azabicyclo[3.1.0]hexane-3-ene derivatives. arylidenmalononitriles and hydroxylamine hydrochloride in the presence of NaOH, under microwave irradiation and solvent-free conditions produced the titled compounds in good to excellent yields. Using of simple chemicals, short reaction times, and solvent-free conditions, high yields of products, high atomic economy , and eco-friendly are the important advantages of this method. The antibacterial effect of 4-amino-2,6-bis(2,4-dichlorophenyl)-1-azabicyclo[3.1.0]hex-3-ene-3,5-dicarbonitrile was evaluated by minimum inhibitory concentration and disk diffusion method against the standard strains of Staphylococcus aureus and Pseudomonas aeruginosa. Minimum inhibitory concentrations of 2h were 40 and 30 mg/ml for P. aeruginosa and S. aureus respectively and the maximum inhibitory zones were 4 and 5 mm on average, respectively.
Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes Keywords:
Microwave-assisted solvent-free synthesis and antibacterial evaluation of 1-azabicyclo[3.1.0]hexane-3-enes authors
Bagher Mohammadi
Payame Noor University of Abhar
Ebrahim Rezaei
Department of Chemistry, Payame Noor University, P. O. Box ۱۹۳۹۵-۳۶۹۷, Tehran, Iran
Fouzieh Moghadami
Department of Biology, Payame Noor University, P. O. Box ۱۹۳۹۵-۳۶۹۷, Tehran, Iran
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