Indium chloride (InCl3) catalysed domino protocol for the regioselective synthesis of highly functionalized pyranopyrazoles under mild conditions
Publish place: Iranian Chemical Communication، Vol: 5، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ICC-5-1_012
تاریخ نمایه سازی: 2 مهر 1398
Abstract:
Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions preceeded within a short period of time with excellent purity. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy. Quantitative yields, inexpensive and environmentally friendly solvent system and simple work-up procedure are the attractive features of the present method. It is thus enviro-economic method without producing hazardous wastes. The formed pyranopyrazoles might find to possess important biological and pharmaceutical applications.
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Authors
Hemant Chavan
Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College Kolhapur, Maharashtra, India
Datta Survase
Department of Chemistry, A.S.P. College Devrukh, Dist-Ratnagiri, Maharashtra, India-۴۱۵۸۰۴
Sakharam Dongare
Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-۴۱۳۲۵۵
Vasant Helavi
Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-۴۱۳۲۵۵
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