The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_RCM-6-2_005

تاریخ نمایه سازی: 16 مهر 1398

Abstract:

Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus, which is the causative agent of adult T-cell leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Evidence suggests that the interaction of HTLV-1 with the cellular-immune system plays a key role in the development of HAM/TSP. However, the main mechanism in this regard remains unknown. The present study aimed to review the HAM/TSP pathogenesis, current status of HTLV-1 in Iran, and available treatments for HTLV-1 infection.

Authors

Masoud Keikha

Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

mohsen Karbalaei Zadeh Babaki

Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

Luiz Augusto Marcondes Fonseca

Institute of Tropical Medicine of São Paulo/ Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, University of São Paulo Medical School, São Paulo, SP ۰۱۲۴۶-۱۰۰, Brazil.

Jorge Casseb

Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, University of São Paulo Medical School, São Paulo, SP ۰۱۲۴۶-۱۰۰, Brazil.

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