Pulsed electromagnetic field attenuated PTSD-induced failure of conditioned fear extinction
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 22، Issue: 6
Publish Year: 1398
Type: Journal paper
Language: English
View: 768
This Paper With 10 Page And PDF Format Ready To Download
- Certificate
- I'm the author of the paper
Export:
Document National Code:
JR_IJBMS-22-6_010
Index date: 12 October 2019
Pulsed electromagnetic field attenuated PTSD-induced failure of conditioned fear extinction abstract
Objective(s): This study aimed to determine whether exposure to pulsed electromagnetic field (PEMF) can impair behavioral failure as induced by PTSD, and also its possible effects on hippocampal neurogenesis. PEMF was used as a non-invasive therapeutic tool in psychiatry.Materials and Methods: Male rats were divided into Control-Sham exposed, Control-PEMF, PTSD-Sham exposed, and PTSD-PEMF groups. PTSD rats were conducted by the single prolonged stress procedures and then conditioned by the contextual fear conditioning apparatus. Control rats were only conditioned. Experimental rats were submitted to daily PEMF (7 mT, 30 Hz for 16 min/day, 14 days). Sham-exposed groups were submitted to the turned off PEMF apparatus. Fear extinction, sensitized fear and anxiety, cell density in the hippocampus, and proliferation and survival rate of BrdU-labeled cells were evaluated. Results: Freezing of PTSD-PEMF rats was significantly lower than PTSD-Sham exposed. In the PTSD-PEMF, center and total crossing in open field, also the percentage of open arms entry and time in the elevated plus maze, significantly increased as compared with PTSD-Sham exposed (P<0.001). Numbers of CA1, CA3, and DG cells in PTSD-PEMF and Control-Sham exposed groups were significantly more than PTSD-Sham exposed (P<0.001). There were more BrdU-positive cells in the DG of the PTSD-PEMF as compared with the PTSD-Sham exposed. Qualitative observations showed an increased number of surviving BrdU-positive cells in the PTSD-PEMF as compared with PTSD-Sham exposed.Conclusion: Using 14-day PEM attenuates the PTSD-induced failure of conditioned fear extinction and exaggerated sensitized fear, and this might be related to the neuroprotective effects of magnetic fields on the hippocampus.
Pulsed electromagnetic field attenuated PTSD-induced failure of conditioned fear extinction Keywords:
Pulsed electromagnetic field attenuated PTSD-induced failure of conditioned fear extinction authors
Mohammad Ali Mohammad Alizadeh
School of Biology, Damghan University, Damghan, Semnan, Iran
Kataneh Abrari
School of Biology, Damghan University, Damghan, Semnan, Iran
Taghi Lashkar Blouki
School of Biology, Damghan University, Damghan, Semnan, Iran
mohammad taghi ghorbanian
School of Biology, Damghan University, Damghan, Semnan, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :