Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 22، Issue: 2
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-22-2_001
تاریخ نمایه سازی: 20 مهر 1398
Abstract:
Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger’s regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. APOE ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, P=0.003; dominant: OR=1.34, 95%CI=1.06-1.68, P=0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with-APOE ε4 genotype than who without-APOE ε4 genotype (OR=0.96, 95%CI=0.16-1.76, P=0.02). Conclusion: APOE ε4 allele increased the depression risk; depressive patients carrying APOE ε4 allele had more severe depressive symptoms.
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Authors
Wei-wei Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
Xiao-lei Liu
The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
Ye Ruan
Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China
Lin Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China
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