From Triggering to iTriggering

Trigger is an essential step in OS for IVF to mimic LH surge; probably the most important injection. The objective of iTriggering is maintain efficacy (securing the optimal num-ber of > 75% mature oocytes, optimal LH activity surge and a subsequent P rise and without compromising fertilization, embryo development and euploidy rates) as well as reduce the risk of OHSS (mortality rate 0.18%- 1).Harvesting oocytes at wrong stage/time impair quality and embryo developmental potential (ideally 16-18 mm; ≥36h). rhCG and uhCG similar pharmacokinetics but different phar-macologic and clinical profile. r-hCG 250mcg better toler-ated, higher P and hCG levels as well as better clinical out - comes.