The Effect of Ethephon on Oxidative Stress Factors in Female Mice

Background: Ethephon is a good and effective plant growth regulator that has the effects on promoting fruit ripening. The most important side effects of ethephon in the body include can-cer, liver disease, kidney disease, impaired reproductive system performance, and infertility. This study was done to investigate the measurement of the oxidative stress system factors in serum samples of ethephon-receiving mice.Materials and Methods: In this study, 50 adult female micewith an average weight of 30 g were used for the experiments. Animals were divided into five groups; control (without receiv-ing any substance), sham (receiving daily serum physiology orally), ethephon 1 (receiving daily 192 mg/kg orally), eth-ephon 2 (receiving daily 240 mg/kg orally), ethephon 3 (re-ceiving daily 480 mg/kg). Oxidative stress markers including malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured in serum samples. The data were analyzed us-ing SPSS version 21 software and the results were expressed as mean ± SD.Results: The results of the experiments showed that ethephon in all three doses reduced the TAC compared to the control group (P<0.05). Also the level of MDA in three doses of eth-ephon-treated mice increased compared to the normal control mice (P<0.05).Conclusion: It can be concluded that an oral administration of ethephon with effect on the oxidative stress system can have a deleterious effect on fertility and embryo development in mice.

Keywords:

Ethephon , Oxidative stress , Fertility , Mice