Premature Ovarian Insufficiency

Women with premature ovarian insufficiency (POI) experi-ence menopause before 40 years of age. This condition affects approximately 1% of women and is associated with multiple health problems such as infertility, osteoporosis, cardiovascular disease and decreased well-being. POI is considered a multi-factorial heterogeneous condition for which the exact underly-ing causes have been identified and associations with autoim-mune disease and environmental factors have been described. Extremely low success rates have been reported with various infertility interventions in women with POI. To date little infor-mation is available concerning the reproductive characteristics of women diagnosed with POI during their preceding reproduc-tive life.