Where is the Difference Brain Region Affected in ADHD Using Seed-based Connectivity Analysis

Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder in which children lose the ability of concentration. ADHD is the Mostly affects children and teens and can continue into adulthood. Problems occurred in the functional connections between different parts of brain can conduce to ADHD. The aim of this study is to analyze the seed-based connectivity of different seeds in the brain and detect the differences between ADHD patients and control participants. Method The ADHD-200 dataset was used and 6 ADHD subjects along with 6 control subjects were studied. The subjects aged between 7-12 years. Acquisition parameters and morphometry information of data are specified in [1]. Functional images were pre-processed to remove artifacts and noise. Then the connectivity process was done for studying seed-based connectivity. Different seeds and their connectivity with other parts of the brain were studied and the T-test was performed in which the voxel threshold P-value was 0.001 and the cluster threshold was 0.05.Results Seed-based connectivity indicated that there is a statistically significant difference in the PITGl (inferior temporal gyrus, left posterior division) seed functional connectivity to the left middle frontal gyrus and the left superior frontal gyrus between two groups in resting state. In which the p-value was less than .05 for cluster-threshold and less than .001 for voxel-threshold for the case control > ADHD these differences are shown in figure1.Conclusions The function of the PITGl is to receive information and the MFGl and SFGl have the inhibitory functions in controlling behaviors [2]. Missing functional connection between these regions in ADHD patients may be the reason why they cannot control their behaviors.