Neural Correlates of Narcolepsy Disorder: An Activation Estimation Likelihood Meta-Analysis
Publish place: 6th iranian human brain mapping congress
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
HBMCMED06_023
تاریخ نمایه سازی: 6 آبان 1398
Abstract:
Narcolepsy, a second prevalent sleep disorder, is characterized by excessive daytime sleepiness, lack of muscle tone triggered by strong emotions that is called cataplexy, sleep paralysis and hallucinations. [1] Narcolepsy also impairs the quality of life and productivity of patients, and increases the risk of accidents. [2] Several structural and functional neuroimaging studies have been conducted in patients with narcolepsy, but they have reported diverse results. Thus, we aimed to determine convergent patterns of abnormal brain function and structure of narcolepsy disorder. Method Based on the preferred reporting for systematic reviews and meta-analyses statement, we had studied 1931 papers from PubMed, Scopus and Ovid databases and retrieved 19 eligible neuroimaging studies. Then, we performed activation estimation likelihood (ALE) meta-analysis to test the convergence among their findings. [3]Results We mainly found a cluster of 73 voxels that shows structural atrophy and dysfunction in frontal orbital cortex, right amygdala and Parahippocampal gyrus - anterior division (p-value 0.007). Conclusions These regions are associated to processing of memory, emotion and decision making. Therefore, these regions and functions play a key role in pathophysiology of narcolepsy.
Authors
Sama Rahimi Jafari
institute of Psychology and Educational Science, Shahid Beheshti University, Tehran, Iran
Sara Sarebannejad
institute of Psychology and Educational Science, Shahid Beheshti University, Tehran, Iran
Masoumeh Rostampoor
Sleep Disorders Research Center, Kermanshah University of Medical Science, Kermanshah, Iran
Habibolah Khazaie
Sleep Disorders Research Center, Kermanshah University of Medical Science, Kermanshah, Iran