Dietary Patterns with Low Level of Plasma Cractive Protein (hs- CRP) may Reduce Systemic Inflammation and Severity of Multiple SclerosisAttacks

Dietary patterns seems to be related to clinical manifestations and anthropometric indices in Multiple Sclerosis (MS). Since MS is a chronic inflammatory disorder of central nervous system, so we tried to find related dietary pattern with systemic inflammation, disease severity, relapse rate, severity of fatigue and anthro pometric measurements and quality of life of MS Patients. This cross- sectional study was conducted in Isfahan, Iran, with four subtypes of 261 MS volunteers (F=210, M=51, mean age 38.98.3). A 168- items food frequency questionnaire (FFQ) serum hs- CRP, multiple sclerosis quality of life- 54 item (MS QOL- 54) questionnaire, extended disability status scale (EDSS), fatigue severity scale (FSS) and visual analog fatigue scale (VAFS) relapse rate, height, weight and Deurenberg Equation were also used as tools. Data were analyzed by SPSS 24, and using ANOVA, tukey, Chi- sqare and ANCOVA tests. among three identified dietary patternsfruits, vegetables, low fat dairy- based pattern (n=51) and Mediterranean- like pattern (n=17) were associated to lower serum hs- CRP (f=6.037), Padjusted (<0.01), higher quality of life (Padjusted <0.05), and chronic fatigue (f= 7.011, Padjusted <0.01), lower BMI (f=7.528, Padjusted <0.01) and percent body fat (f= 6.135, Padjusted <0.01), but no difference was observed about EDSS across the patterns. The most of variables, had significant differences between two mentioned patterns and western- like pattern (n=194). These associationspersist when adjusting for age, sex, disease duration and subtypes. adherence to healthy dietary patterns may reduce systemic inflammation, severity of fatigue, MS attacks, improve quality of life and normalize weight especially body fat in MS patients.