The Significant Impact of Apigenin on Different Aspects of Autoimmune Disease

Systemic autoimmune diseases like Multiple sclerosis and Rheumatoid arthritis are among the highest diseases to diagnose and treat.The current gold standard of care for these diseases is immunosuppressive drugs which interfere with overall immune responses; their long-term high-dose treatments would expose the patient to opportunistic, life-threatening and long-term malignant infections. Considering the side effects and toxicity of these drug and also the beneficial effects of herbal compounds among their consumers, the professional investigation on the exact mechanism of the plant’s major element has grown much attention in the last years. Apigenin as an extracting compound of plants, such as parsley and celery, which has a variety of biological effects, such as anti-inflammatory, anti-cancer and antioxidant effects. This review is intended to summarize the various effects of Apigenin on several autoimmune diseases such asmultiple sclerosis which have been worked on so far.The pluralization of the obtained results has revealed Apigenin’s effects on pro inflammatory cytokines such as IL-1β and IL6, chemokines such as ICAM-1, immune cells proliferation such as T cells, apoptosis, and varioussignaling pathways. Conclusion: According to these preclinical findings, we recommend that further robust unbiased studies should be done to use Apigenin as a supplementary or therapeutic element for treating the inflammatory autoimmune disease in the central nervoussystem or other organs.