Gestational Trophoblastic Neoplasm; Case Series and Literature Review

Objective: Appropriated management of patients with advanced of Gestational Trophoblastic Neoplasm (GTN) appear to be a great deal. This study was conducted to evaluate the value of the imaging method of fluorine-18-fluorodeoxyglucose positron emission/Computed tomography scanning (PET/CT) in treatment planning and outcome in patients with GTN and localizing of metastatic site.Methods: A retrospective study on four patients with persistent GTN who had been studied with whole body PET/CT to detected the extension of tumor. Based on these data all our patients underwent surgery, therefor clinical impact strength of PET/CT had been analysis.Results: In 3 of 4 cases the PET/CT had positive accordance with other anatomical and clinical impact. In one case the PET/CT not enable detected the source of viable neoplasm.Conclusion: The additional value of the PET/CT with respect to other imaging modality; mainly is in differentiating between residual viable tumor tissue and necrosis, in discloser of chemo resistant lesion in GTN. Due to the expensive equipment despite of its value, unfortunately PET/CT, its use is limited in certain cases to detected the source of viable neoplasm.

Keywords:

Chemo resistance , Gestational trophoblastic tumor , FDG PET/CT Scan