Value of microRNAs in Endometriosis

Backgrounds: This review will focus on miRNAs in endometriosis, a common chronic disease that affecting nearly 10% of fertility age in women[1]. Endometriosis is exemplified as overgrowth of endometrial tissue outside .MicroRNAs (miRNAs) are impressive regulators of gene expression that regulate gene expression at the levels of the post translation in some biological processes [2]. miRNAs and their target mRNAs are differentially expressed in endometriosis and other disorders of the female reproductive system This molecular RNAs are set up several biological processes [3, 4] and they contribute as biomarker[5]. Dysregulated miRNA expression has been analyzed in diseases of the female reproductive system, including gynecologic cancers (ovarian, cervical, and endometrial[6].many study has showed, miRNAs as potentially robust biomarkers for endometriosis[45]. A study in Iran has shown that Of 441 infertile women, 82 (18.6%) had endometriosis. [7]The presence of distinct miRNA profiles between endometriotic and nonendometriotic tissues indirectly indicates that miRNA may have a function in the pathophysiology of endometriosis. Types of microRNAs role in endometriosis is contain of microRNAs function in inflammation, cell survival, angiogenesis and cell invasion and proliferation and apoptosis[8].Material and Method: in this review, the related articles for this subject were collected from international databases such as PubMed, Scopus and ISI.Result: MicroRNAs are noncoding RNA fragments that regulate gene expression at the levels of the post translation in aspects of biology[9, 10]and abnormal expression of miRNAs has been associated with various disorders[11]. MiRNAs may play an important role in endometriotic lesion development[9]. Detail profiling of miRNAs and/or siRNAs may serve as an important tool for endometriosis diagnosis. Conclusion: However, as a non-invasive method, expression of microRNAs could be used as biomarkers distinguishing endometriosis patients and may prove to be instrumental to tracking how a patient responds to a particular drug also they could perhaps help to explain the pathogenesis of disease. Clinical implementation of a miRNA-based endometriosis diagnostic is essential.