Evaluation of serum levels of 25-hydroxyvitamin D with acute exacerbation of chronic obstructive pulmonary disease

Introduction: Vitamin D deficiency is a general widespread issue in adults and may be a risk factor for respiratory disease; it is associated with reduced lung function and chronic obstructive pulmonary disease. The main aim of this study is the evaluation of serum levels of 25-hydroxyvitamin D with acute exacerbation of chronic obstructivepulmonary disease (AECOPD). MaterialS and Methods: This study is a cross sectional study in which the statistical society was 80 patients with AECOPD referring to Imam Reza Hospital Mashhad University of Medical Sciences during 2016-2017. 3 cc blood samples were taken from eligible patients for evaluating the serum levels of 25-hydroxyvitamin D by hospitalization up to 24 hours after that. Then, the increase in acute attack of patients was measured by using the number of acute attacks over the past year, with the recent attack, the severity of chronic respiratory disease spirometry with determination of FEV1 after patient situation stability , the level of hypoxemia. Finally, the gathered data were analyzed by using SPSS20 software. Results: The results of this study showed a higher percentage of COPD prevalence in male gender. The mean age of patients was 58.02 ± 9.86 years. There was a significant relationship between the mean serum levels of 25-hydroxyvitamin D and the sex of the patients (P=0.01), and the mean serum level of 25-hydroxyvitamin D was lower in female. However, there was no significant relationship between the mean serum 25- hydroxyvitamin D level and patient s age (P=0.3). 42 patient in this study had a history of smoking, of which 92.9% were male and 1.7% were female. The most common complaints of patients during hospitalization included dyspnea (93.8%), cough (91.3%), and phlegm (85.0%). There was no significant relationship between mean serum levels 25-hydroxyvitamin D and hospitalization time (P=0.1). But there was a significant correlation between the mean serum levels of 25-hydroxyvitamin D and the increased acute attack frequency in COPD patients (P=0.01), with an average of 2 and more than 2 times the acute attack during the last year. There was also a significant relationship between mean serum levels 25-hydroxyvitamin D and the hypoxemia level in patients (P=0.01) and the mean serum levels of vitamin D were lower in patients with hypoxemia levels below 60-70 mm Hg. There was a significant relationship between mean serum levels 25-hydroxyvitamin D and blood PH in patients (P=0.03) and the mean serum levels of vitamin D were lower in patients with a pH below 7.25. Conclusion: Overall, given the potential relationship between vitamin D deficiency and the acute attack of chronic obstructive pulmonary disease, this study recommend vitamin D deficiency correction .

Keywords:

COPD , Spirometry , Vit D.