Evaluating the level of serum NFL in different phenotype of MS disease and comparing it with healthy control

Multiple sclerosis (MS) is one of the most common CNS disease in Iran and all over the world. It has a wide spectrum of clinical manifestation from involvement of sensory-motor system and visual system as well. MS disease is a progressive disease therefore, predicting the disease in early stages can reduce the burden of disease. One of the main pathology in MS disease is axonal loss and neurodegeneration so that an objective biomarker to detect and quantify axonal loss could be useful in early diagnosis. Neurofilaments (NFL) are major components of the cytoskeleton of neurons. They belong to intermediate protein filament. They are divided into three subgroup according on their molecular weight, neurofilament light chain (NFL), neurofilament intermediate chain (NFM) and neurofilament heavy chain (NFH). When axons damage in CNS or peripheral nervous system, NFs release within cerebrospinal fluid ( CSF) and blood stream, so we can use of these fluids for detecting and evaluating of neurofilaments. There is not any clinical and paraclinical method to detect the prognosis of MS disease, so evaluating of neurofilaments could be helpful to diagnosis the disease in early stages. We are going to study the level of NFL in serum of different type of MS patients and comparing them with health control people by using NFL as a new biomarker for prognosis of MS.In this study we are evaluating 5 groups, CIS.RRMS, PPMS, SPMS and HC and in each one have 30 cases . preliminary of the results will be present in the congress.

Keywords:

MS , Neurofilaments , Progressive MS , RRMS , CIS