99mTc-SPION-Chitosan: Potential of Dual-modality Nanoparticle probes in Nuclear Medicine

Background: Due to excellent biocompatibility and biodegradability of Chitosan and many applications of SPION, have been used extensively in pharmaceutical application and radiopharmaceutical in nuclear medicine. So the aim of study was evaluating potential of Chitosan-Coated SPION labeled with 99mTc as new Dual-modality probes in Nuclear Medicine.Methods: In this Experimental study chitosan particles were coated on SPION and were used DLS and SEM for size distribution and morphology of particle. Labeling efficiency and stability of Chitosan-SPION with 99mTc were cheeked. Finally, Biodistribution study, MRI and nuclear medicine imaging in Balb/c mice after injection of complex were performed.Results: Results showed that the final complex have spherical shape and with average size 255±30nm. The labeling efficiency and stability of complex with 99mTc were 89±6%, 93±6% respectively. Biodistribution study, MRI and nuclear medicine imaging showed high accumulation of Complex in liver.Conclusion: The results showed that the 99mTc-Chitosan-SPION may be considered as a suitable Dual-modality radiopharmaceutical in Nuclear medicine.

99mTc-SPION-Chitosan: Potential of Dual-modality Nanoparticle probes in Nuclear Medicine Keywords:

Nuclear medicine , MRI , Dual-modality , Chitosan , SPION