Evolution of Plasma Assisted Non-Invasive Surgery (PANIS) in conjunctivochalasis treatment

Purpose: In recent years Atmospheric Low Temperature Plasma (ALTP) used as a new treatment modalities in various medical fields like dermatology, pharmacology, ... and even cancer treatment. The purpose of this study, after proved the safety in animal models is to show that we can use (ALTP) as a non-invasive surgery to treat Conjunctivochalasis (Cch) . Methods: This study included 38 eyes (22 patients) with Cch (Grade 3 and 2). Five parameters were measured at 1 week,1, 3 and 6 months after the surgery, grading of Cch ,height of tear meniscus, corneal fluorescein staining, tear break-up time (TBUT) and ocular surface disease index (OSDI). In this study plasma spots with the distance of 4 mm from limbus (depending on the Cch grading) are placed in 2 to 3 rows on the loose conjunctiva. All patients were treated with short course of topical steroid and antibiotic. The PANIS method was performed by using plasma generator (Plexr, GMV, Italy). Results: During follow up in 90% of patients, grading has reduced from 3 to 1.In all patients the height of tear mesicus has not changed. In all patients corneal fluorescein staining is completely cleared. TBUT has no significant change. In 85% of patients the average of OSDI is reduced from 50 to 10. Conclusion: Atmospheric Low Temperature Plasma is office-based new treatment modalities in Conjunctivochalasis surgery and it seems safe and efficient.